Article

Cardiomyopathy-Associated and Basic Residue Mutations in Myopalladin Alter Actin Binding, Bundling, and Structural Stability

2025-09-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Myopalladin (MYPN) is a striated muscle-specific sarcomeric protein belonging to the immunoglobulin (Ig)-domain-containing family of actin regulators. The Ig3 domain of MYPN is indispensable for interacting with and stabilizing actin filaments, and an increasing number of cardiomyopathic (CM)-associated mutations have been identified within this domain, highlighting its impo...

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Literature Corpus work: 8c26879b-3656-5ce4-903f-119f53c2f42b
DOI: 10.1101/2025.09.18.677238

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