Article
A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis.
PloS one - 25 Nov 2009
Oude Ophuis Ralph J A, Wijers Mietske, Bennink Miranda B, van de Loo Fons A J, Fransen Jack A M, Wieringa Bé, Wansink Derick G
Abstract excerpt
BACKGROUND: Studies on the myotonic dystrophy protein kinase (DMPK) gene and gene products have thus far mainly concentrated on the fate of length mutation in the (CTG)n repeat at the DNA level and consequences of repeat expansion at the RNA level in DM1 patients and disease models. Surprisingly little is known about the function of DMPK protein products. METHODOLOGY/PRINCIPAL FINDINGS: We demonstrate here that...
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