Article

High Throughput Screening with a Primary Human Mucociliary Airway Model Identifies a Small Molecule with Anti-SARS-CoV-2 Activity

2024-05-10

Abstract excerpt

<h4>Summary</h4> Respiratory viruses (e.g. influenza, RSV, SARS etc.) attack the proximal airway and cause a wide spectrum of diseases for which we have limited therapies. To date, a few primary human stem cell-based models of the proximal airway have been reported for drug discovery but scaling them up to a higher throughput platform remains a significant challenge. Here we present a microscale, primary human st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d41e13e1-620e-597a-b7e4-bb515671a4d6
DOI: 10.1101/2024.05.09.593388

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High Throughput Screening with a Primary Human Mucociliary Airway Model Identifies a Small Molecule with Anti-SARS-CoV-2 ActivityDOI 10.1101/2024.05.09.593388Read

A human primary airway microphysiological system infected with SARS-CoV-2 distinguishes the treatment efficacy between nirmatrelvir and repurposed compounds fluvoxamine and amodiaquineSemantic proximity Read

Development of robust antiviral assays using relevant apical-out human airway organoidsSemantic proximity Read

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung OrganoidsSemantic proximity Read

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variantsSemantic proximity Read

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19Semantic proximity Read

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epitheliumSemantic proximity Read

Recapitulating SARS-CoV-2 Infection in a Human Lung Organoid-on-a-Chip at the Air-Liquid InterfaceSemantic proximity Read

Identification and Targeting of Regulators of SARS-CoV-2-Host Interactions in the Airway EpitheliumSemantic proximity Read

Human airway organoids model SARS-CoV-2 high infectiousness and evasion of interferon responseSemantic proximity Read

Identification and Targeting of Regulators of SARS-CoV-2-Host Interactions in the Airway Epithelium.Semantic proximity Read

Protocol for primary human lung organoid-derived air-liquid interface <i>in vitro</i> model to study response to SARS-CoV-2Semantic proximity Read