Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants

23 Feb 2023

Abstract excerpt

Ancestral SARS coronavirus-2 (SARS-CoV-2) and variants of concern (VOC) caused a global pandemic with a spectrum of disease severity. The mechanistic explaining variations related to airway epithelium are relatively understudied. Here, we biobanked airway organoids (AO) by preserving stem cell function. We optimized viral infection with H1N1/PR8 and comprehensively characterized epithelial responses to SARS-CoV-2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neonatal Respiratory Health Research
Share to Respiratory Support and Mechanisms
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36827975
DOI: 10.1016/j.stemcr.2023.01.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variantsPMID 36827975Read ↗

SARS-CoV-2 Infection of Lung Organoids Reveals Conserved Use of Tetraspanin-8 by Ancestral-, Delta-, and Omicron- VariantsSemantic proximity Read ↗

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19Semantic proximity Read ↗

Human airway organoids model SARS-CoV-2 high infectiousness and evasion of interferon responseSemantic proximity Read ↗

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19Semantic proximity Read ↗

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epitheliumSemantic proximity Read ↗

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epitheliumSemantic proximity Read ↗

Single-cell analysis of lung epithelial cells reveals age and cell population-specific responses to SARS-CoV-2 infection in ciliated cellsSemantic proximity Read ↗

The use of human iPSC‐derived alveolar organoids to explore SARS‐CoV‐2 variant infections and host responsesSemantic proximity Read ↗

SARS-CoV-2 Omicron efficiently infects human airway, but not alveolar epitheliumSemantic proximity Read ↗

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19Semantic proximity Read ↗

SARS-CoV-2 Omicron BA.2.86 & JN.1 shifting tropism from airway to intestineSemantic proximity Read ↗

Uncovering strain- and age-dependent differences in innate immune response to SARS-CoV-2 infection in nasal epithelia using 10X single-cell sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.