Evaluation of Epigenetic Silencing of the miR-139-5p gene in the pathogenesis of colorectal cancer and its diagnostic biomarker capability in plasma samples

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: The pathogenesis of CRC requires primary genetic and epigenetic mechanisms including, methylation of CpG islands of the genes. In the current study, micro RNA-139-5p (<italic>miR</italic>-139-5p) promoter methylated DNA was evaluated in tumor tissue and plasma samples from CRC affected patients. <bold>Methods: </bold><italic>MiR</italic>-139-5p promoter methylat...

Topics

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• Base Sequence
• Case-Control Studies
• Colorectal Neoplasms
• Gene Frequency
• Genetic Predisposition to Disease
• MicroRNAs
• Polymorphism, Single Nucleotide
• Smad7 Protein

Identifiers and source

Literature Corpus work

d4050e35-4753-58fb-b17d-56cb1b274e7b

DOI

10.21203/rs.3.rs-5527622/v1