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Article

KRAS Mutation-Responsive miR-139-5p inhibits Colorectal Cancer Progression and is repressed by Wnt Signaling.

Theranostics - 1 Jan 2020

Du Feng, Cao Tianyu, Xie Huahong, Li Ting, Sun Lina, Liu Hao, Guo Hao, Wang Xin, Liu Qi, Kim Taewan, Franklin Jeffrey L, Graves-Deal Ramona, Han Weili, Tian Zuhong, Ge Minghui, Nie Yongzhan, Fan Daiming, Coffey Robert J, Lu Yuanyuan, Zhao Xiaodi

Abstract excerpt

Introduction: Colorectal cancer (CRC) frequently harbors KRAS mutations that result in chemoresistance and metastasis. MicroRNAs (miRNAs) are usually dysregulated and play important regulatory roles in tumor progression. However, the KRAS mutation-responsive miRNA profile in CRC remains uninvestigated. Methods: miR-139-5p was identified and evaluated by small RNA sequencing, qRT-PCR and in situ hybridization. The...

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Identifiers

PMID: 32641995
DOI: 10.7150/thno.45971
PMCID: PMC7330859

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