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Genetically engineered T cells for the treatment of cancer

19 Jan 2013

Abstract excerpt

T-cell immunotherapy is a promising approach to treat disseminated cancer. However, it has been limited by the ability to isolate and expand T cells restricted to tumour-associated antigens. Using ex vivo gene transfer, T cells from patients can be genetically engineered to express a novel T cell receptor or chimeric antigen receptor to specifically recognize a tumour-associated antigen and thereby selectively...

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PMID: 23198862
DOI: 10.1111/joim.12020

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