Article

Machine Learning-based Approaches for Identifying Human Cells Harboring Fetal Chromatin Domain Ablations

2021-09-22

Abstract excerpt

Two common hemoglobinopathies, sickle cell disease (SCD) and β-thalassemia, arise from genetic mutations within the β-globin gene. A 500-bp motif termed Fetal Chromatin Domain (FCD), upstream of human ϒ-globin locus, may function as a transcriptional regulatory element driving inhibition of the ϒ-globin gene. Here, we hypothesize that the removal of this motif using CRISPR technology may reactivate the expression...

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Literature Corpus work: d3b7cca3-6950-5525-bdce-63f751efa73d
DOI: 10.21203/rs.3.rs-906377/v1

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