Article

Dissecting polycomb complexes for enhanced fetal hemoglobin production

2026-04-18

Abstract excerpt

Polycomb repressive complexes PRC1 and PRC2 regulate diverse developmental processes, including the fetal-to-adult switch in hemoglobin production, a process whose reversal is a goal for the treatment of sickle cell disease and β-thalassemia. PRC inhibitors show promise for various disorders, but use is limited because of pleiotropic PRC activities. We explored whether fetal hemoglobin (HbF) can be reactivated in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 15f83132-0284-5912-9497-1d48fdf42991
DOI: 10.64898/2026.04.16.718974

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dissecting polycomb complexes for enhanced fetal hemoglobin productionDOI 10.64898/2026.04.16.718974Read

Molecular basis of polycomb group protein-mediated fetal hemoglobin repressionSemantic proximity Read

Identification of novel γ-globin inducers among all potential erythroid druggable targetsSemantic proximity Read

Dissecting the epigenetic regulation of the fetal hemoglobin genes to unravel a novel therapeutic approach for β-hemoglobinopathiesSemantic proximity Read

Epigenetic Regulation of β-Globin Genes and the Potential to Treat Hemoglobinopathies through Epigenome EditingSemantic proximity Read

Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathiesSemantic proximity Read

C2H2 Zinc Finger Transcription Factors Associated with HemoglobinopathiesSemantic proximity Read

Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locusSemantic proximity Read

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11ASemantic proximity Read

Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34 <sup>+</sup> cell therapy to induce fetal hemoglobin for sickle cell diseaseSemantic proximity Read

CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell diseaseSemantic proximity Read

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expressionSemantic proximity Read

Update on fetal hemoglobin gene regulation in hemoglobinopathiesSemantic proximity Read