Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic Regulation of β-Globin Genes and the Potential to Treat Hemoglobinopathies through Epigenome Editing

25 Feb 2023

Abstract excerpt

Beta-like globin gene expression is developmentally regulated during life by transcription factors, chromatin looping and epigenome modifications of the β-globin locus. Epigenome modifications, such as histone methylation/demethylation and acetylation/deacetylation and DNA methylation, are associated with up- or down-regulation of gene expression. The understanding of these mechanisms and their outcome in gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cannabis and Cannabinoid Research
Share to Epigenetics and DNA Methylation
Share to Hemoglobinopathies and Related Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36980849
DOI: 10.3390/genes14030577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic Regulation of β-Globin Genes and the Potential to Treat Hemoglobinopathies through Epigenome EditingPMID 36980849Read ↗

Dissecting the epigenetic regulation of the fetal hemoglobin genes to unravel a novel therapeutic approach for β-hemoglobinopathiesSemantic proximity Read ↗

Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies.Semantic proximity Read ↗

Recent advance on genome editing for therapy of β-hemoglobinopathies.Semantic proximity Read ↗

Exploring epigenetic and microRNA approaches for γ-globin gene regulationSemantic proximity Read ↗

Genome Editing for β-Hemoglobinopathies: Advances and ChallengesSemantic proximity Read ↗

Customizing the genome as therapy for the β-hemoglobinopathiesSemantic proximity Read ↗

Epigenetic regulation of fetal globin gene expression in adult erythroid cellsSemantic proximity Read ↗

Therapeutic gene editing strategies using CRISPR-Cas9 for the β-hemoglobinopathiesSemantic proximity Read ↗

A Small Key for a Heavy Door: Genetic Therapies for the Treatment of HemoglobinopathiesSemantic proximity Read ↗

CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cellsSemantic proximity Read ↗

A Review of Gene Therapies for HemoglobinopathiesSemantic proximity Read ↗

C2H2 Zinc Finger Transcription Factors Associated with HemoglobinopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.