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Article

Machine learning-based approaches for identifying human blood cells harboring CRISPR-mediated fetal chromatin domain ablations.

Scientific reports - 27 Jan 2022

Li Yi, Zaheri Shadi, Nguyen Khai, Liu Li, Hassanipour Fatemeh, Pace Betty S, Bleris Leonidas

Abstract excerpt

Two common hemoglobinopathies, sickle cell disease (SCD) and β-thalassemia, arise from genetic mutations within the β-globin gene. In this work, we identified a 500-bp motif (Fetal Chromatin Domain, FCD) upstream of human ϒ-globin locus and showed that the removal of this motif using CRISPR technology reactivates the expression of ϒ-globin. Next, we present two different cell morphology-based machine learning...

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Identifiers

PMID: 35087158
DOI: 10.1038/s41598-022-05575-3
PMCID: PMC8795181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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