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Article

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells

3 Feb 2018

Abstract excerpt

Etoposide (ETP) and anthracyclines are applied for wide anti-cancer treatments. However, the ETP-induced cardiotoxicity remains to be a major safety issue and the underlying cardiotoxic mechanisms are not well understood. This study is aiming to unravel the cardiotoxicity profile of ETP in comparison to anthracyclines using physiologically relevant human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29397400
DOI: 10.1007/s00204-018-2170-7

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