HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the <i>EWSR1</i> promoter in Ewing sarcoma

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma (EWS) is an aggressive developmental sarcoma driven by a fusion gene, EWSR1-FLI1. However, little is known about the regulation of EWSR1-FLI1 chimeric fusion gene expression. Here, we demonstrate that active nuclear HDAC6 in EWS modulates acetylation status of specificity protein 1 (SP1), consequently regulating SP1/P300 activator complex binding to EWSR1 and EWSR1-FLI1 promoters....

Topics

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• Acute Myeloid Leukemia Research
• Cancer Genomics and Diagnostics
• Cell death mechanisms and regulation
• Histone Deacetylase Inhibitors Research
• Neuroblastoma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Sarcoma Diagnosis and Treatment

Identifiers and source

Literature Corpus work

d3a40e6e-77e2-55d5-bf7d-3621fa9fdccc

DOI

10.1101/2021.01.04.425179