Article

Class I Histone Deacetylases (HDAC) Critically Contribute to Ewing Sarcoma Pathogenesis

2021-06-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Histone acetylation and deacetylation seem processes involved in the pathogenesis of Ewing sarcoma (EwS). Here histone deacetylases (HDAC) class I were investigated.<bold>Methods:</bold> Their role was determined using different inhibitors including TSA, Romidepsin, Entinostat and PCI-34051 as well as CRISPR/Cas9 class I HDAC knockouts and HDAC RNAi. To analyze...

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Literature Corpus work: 12cfb8d2-5083-5cba-bcb6-e0a7796264ac
DOI: 10.21203/rs.3.rs-614360/v1

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