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Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

15 Oct 2021

Abstract excerpt

BACKGROUND: Histone acetylation and deacetylation seem processes involved in the pathogenesis of Ewing sarcoma (EwS). Here histone deacetylases (HDAC) class I were investigated. METHODS: Their role was determined using different inhibitors including TSA, Romidepsin, Entinostat and PCI-34051 as well as CRISPR/Cas9 class I HDAC knockouts and HDAC RNAi. To analyze resulting changes microarray analysis, qRT-PCR,...

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PMID: 34654445
DOI: 10.1186/s13046-021-02125-z

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