Article
Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2.
Genome biology - 27 Jan 2021
Specht Harrison, Emmott Edward, Petelski Aleksandra A, Huffman R Gray, Perlman David H, Serra Marco, Kharchenko Peter, Koller Antonius, Slavov Nikolai
Abstract excerpt
BACKGROUND: Macrophages are innate immune cells with diverse functional and molecular phenotypes. This diversity is largely unexplored at the level of single-cell proteomes because of the limitations of quantitative single-cell protein analysis. RESULTS: To overcome this limitation, we develop SCoPE2, which substantially increases quantitative accuracy and throughput while lowering cost and hands-on time by...
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