Article

Acute exercise increases systemic kynurenine pathway metabolites and activates the AHR in human PBMCs

2024-01-20

Abstract excerpt

The kynurenine pathway of tryptophan degradation generates several metabolites such as kynurenine or kynurenic acid that serve as endogenous ligands of the aryl hydrocarbon receptor (AHR). Due to its distinct biological roles particularly modulating the immune system, the AHR is a current therapeutic target across different inflammation-related diseases. Here, we show an exercise-induced increase in AHR ligand ava...

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Literature Corpus work: d376598f-38bf-5611-8943-22778fef967b
DOI: 10.1101/2024.01.17.576018

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Acute exercise increases systemic kynurenine pathway metabolites and activates the AHR in human PBMCsDOI 10.1101/2024.01.17.576018Read

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