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Article

Immunomodulatory actions of a kynurenine-derived endogenous electrophile

2022-02-10

Abstract excerpt

The inflammatory upregulation of kynurenine metabolism induces immunomodulatory responses via incompletely understood mechanisms. We report that increases in cellular and systemic kynurenine levels yield the electrophilic derivative kynurenine-carboxyketoalkene (Kyn-CKA), as evidenced by the accumulation of thiol-conjugates and saturated metabolites. Under physiological conditions, Kyn-CKA induces Nrf2-regulated g...

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Literature Corpus work
4b84b03c-1c20-5764-a32e-843e55132b96
DOI
10.1101/2022.02.08.479451
Open publication

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Immunomodulatory actions of a kynurenine-derived endogenous electrophileDOI 10.1101/2022.02.08.479451
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