Elucidating the molecular determinants of Aβ aggregation with deep mutational scanning

Abstract excerpt

Despite the importance of Aβ aggregation in Alzheimer’s disease etiology, our understanding of the sequence determinants of aggregation is sparse and largely derived from in vitro studies. For example, in vitro proline and alanine scanning mutagenesis of Aβ 40 proposed core regions important for aggregation. However, we lack even this limited mutagenesis data for the more disease-relevant Aβ 42 . Thus, to bett...

Topics

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• Alzheimer Disease
• Alzheimer's disease research and treatments
• Amyloid
• Amyloid beta-Peptides
• Bioinformatics and Genomic Networks
• Cholinesterase and Neurodegenerative Diseases
• Computational Drug Discovery Methods
• Genomics and Rare Diseases

Identifiers and source

Literature Corpus work

1bdaf07c-e76a-59e3-b457-9c1cd15fa894

DOI

10.1101/662213