Article

Affinity Maturation and Characterization of the Novel Monoclonal Antibody (mAb) PB-223 Targeting Cancer- Specific Core 2 O-Glycans

2026-06-03

Abstract excerpt

<h4>Background: </h4> Enhancing the binding affinity of monoclonal antibodies (mAbs) has the potential to improve their therapeutic efficacy. In this study, we generated a novel mAb, PB-223, through affinity maturation of the parental antibody NEO-102. NEO-102 (Ensituximab) is a chimeric human IgG1 mAb that targets a cancer-specific glycosylated variant of MUC5AC expressed on colorectal and pancreatic cancers, whi...

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Literature Corpus work: d3736d3b-37d2-572d-9fb7-857acb1d4627
DOI: 10.20944/preprints202606.0312.v1

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