Article

Engineering affinity-matured variants of an anti-polysialic acid monoclonal antibody with superior cytotoxicity-mediating potency

2025-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Monoclonal antibodies (mAbs) that specifically recognize cell surface glycans associated with cancer and infectious disease hold tremendous value for both basic research and clinical applications. However, high-quality anti-glycan mAbs, especially those with sufficiently high affinity and specificity, remain scarce, highlighting the need for protein engineering approaches based on rational desig...

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Literature Corpus work: a1075d0f-9d47-507e-bf86-e491bcebfd32
DOI: 10.1101/2025.02.12.637914

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