Article

Sphingosine-1-phosphate regulates Plasmodium histone deacetylase activity and exhibits epigenetic control over cell death and differentiation

2022-06-09

Abstract excerpt

Histone deacetylases (HDACs) play a key role in cellular processes by the regulation of gene transcription. This study contributes a novel insight how Plasmodium falciparum HDAC ( Pf HDAC-1) is regulated by S1P produced by host erythrocyte SphK-1. The binding of S1P with endogenous nuclear extract Pf HDAC-1 and recombinant Pf HDAC-1 blocks their activity. A significant modulation in transcriptional regulation...

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Literature Corpus work: d3709ffb-6d4d-598a-8bc3-57860729c76c
DOI: 10.1101/2022.06.09.495418

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