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Activity-based protein profiling of human and plasmodium serine hydrolases and interrogation of potential antimalarial targets

23 Aug 2022

Abstract excerpt

Malaria remains a global health issue requiring the identification of novel therapeutic targets to combat drug resistance. Metabolic serine hydrolases are druggable enzymes playing essential roles in lipid metabolism. However, very few have been investigated in malaria-causing parasites. Here, we used fluorophosphonate broad-spectrum activity-based probes and quantitative chemical proteomics to annotate and...

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PMID: 36105595
DOI: 10.1016/j.isci.2022.104996

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