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Histone 4 lysine 8 acetylation regulates proliferation and host–pathogen interaction in Plasmodium falciparum

22 Aug 2017

Abstract excerpt

BACKGROUND: The dynamics of histone modifications in Plasmodium falciparum indicates the existence of unique mechanisms that link epigenetic factors with transcription. Here, we studied the impact of acetylated histone code on transcriptional regulation during the intraerythrocytic developmental cycle (IDC) of P. falciparum. RESULTS: Using a dominant-negative transgenic approach, we showed that acetylations of...

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PMID: 28830512
DOI: 10.1186/s13072-017-0147-z

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