Article
Plasmodium falciparum: epigenetic control of var gene regulation and disease.
Sub-cellular biochemistry - 1 Jan 2013
Deshmukh Abhijit S, Srivastava Sandeep, Dhar Suman Kumar
Abstract excerpt
Plasmodium falciparum, one of the deadliest parasites on earth causes human malaria resulting one million deaths annually. Central to the parasite pathogenicity and morbidity is the switching of parasite virulence (var) gene expression causing host immune evasion. The regulation of Plasmodium var gene expression is poorly understood. The complex life cycle of Plasmodium and mutually exclusive expression pattern...
Topics
- Acetylation
- Animals
- Antimalarials
- Chromatin
- Chromatin Assembly and Disassembly
- Drug Resistance
- Epigenesis, Genetic
- Gene Expression Regulation
- Genotype
- Histone Acetyltransferases
- Histone Deacetylase Inhibitors