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Article

Histone deacetylase inhibitors with high in vitro activities against Plasmodium falciparum isolates collected from Gabonese children and adults.

Scientific reports - 22 Nov 2019

Koehne Erik, Kreidenweiss Andrea, Zoleko Manego Rella, McCall Matthew, Mombo-Ngoma Ghyslain, Mackwitz Marcel Karl Walter, Hansen Finn K, Held Jana

Abstract excerpt

Histone deacetylase (HDAC) enzymes are targets for the development of antimalarial drugs with a different mode of action to established antimalarials. Broad-spectrum HDAC-inhibitors show high potency against Plasmodium falciparum, but displayed some toxicity towards human cells. Inhibitors of human HDAC6 are new drug candidates with supposed reduced toxicity to human cells and favorable activities against...

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Identifiers

PMID: 31758015
DOI: 10.1038/s41598-019-53912-w
PMCID: PMC6874535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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