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Schwann cell release of p11 induces sensory neuron hyperactivity in Fabry disease

2023-05-28

Abstract excerpt

Patients with Fabry disease suffer from chronic debilitating pain and peripheral sensory neuropathy with minimal treatment options, but the cellular drivers of this pain are unknown. Here, we propose a novel mechanism by which altered signaling between Schwann cells and sensory neurons underlies the peripheral sensory nerve dysfunction we observe in a genetic rat model of Fabry disease. Using in vivo and in vitr...

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Literature Corpus work
437ab13e-a09d-5f0d-8070-3d83ec3190ce
DOI
10.1101/2023.05.26.542493
Open publication

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Schwann cell release of p11 induces sensory neuron hyperactivity in Fabry diseaseDOI 10.1101/2023.05.26.542493
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