Article

The lipid landscape shapes the immunomodulatory potential of fluoxetine in macrophages

2026-08-28

Abstract excerpt

Treatment-resistant depression (TRD) affects approximately one-third of depressed patients, yet the molecular mechanisms underlying this therapeutic non-responsiveness remain unclear. Pharmacological antidepressants, such as the selective serotonin reuptake inhibitor (SSRI) fluoxetine, exert immunomodulatory effects, partially by shifting macrophages towards an anti-inflammatory phenotype. Clinical aberrations in...

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Literature Corpus work: d35c1852-6cd1-5c18-a179-10b016ebd44a
DOI: 10.64898/2026.08.25.746975

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