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Article

Downregulation of monocytic differentiation via modulation of CD147 by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

PloS one - 1 Jan 2017

Sasidhar Manda V, Chevooru Sai Krishnaveni, Eickelberg Oliver, Hartung Hans-Peter, Neuhaus Oliver

Abstract excerpt

CD147 is an activation induced glycoprotein that promotes the secretion and activation of matrix metalloproteinases (MMPs) and is upregulated during the differentiation of macrophages. Interestingly, some of the molecular functions of CD147 rely on its glycosylation status: the highly glycosylated forms of CD147 induce MMPs whereas the lowly glycosylated forms inhibit MMP activation. Statins are...

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Identifiers

PMID: 29253870
DOI: 10.1371/journal.pone.0189701
PMCID: PMC5734787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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