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Article

Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes.

Journal of cell science - 15 Feb 2024

Kamada Yoshiaki, Umeda Chiharu, Mukai Yukio, Ohtsuka Hokuto, Otsubo Yoko, Yamashita Akira, Kosugi Takahiro

Abstract excerpt

Certain proteins assemble into diverse complex states, each having a distinct and unique function in the cell. Target of rapamycin (Tor) complex 1 (TORC1) plays a central role in signalling pathways that allow cells to respond to the environment, including nutritional status signalling. TORC1 is widely recognised for its association with various diseases. The budding yeast Saccharomyces cerevisiae has two types...

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Identifiers

PMID: 38415789
DOI: 10.1242/jcs.261625
PMCID: PMC10941655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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