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Combination of isoflurane and propofol as general anaesthesia during orthopaedic surgery of perioperative cerebral hypoperfusion rats to avoid cognitive impairment Anaesthesia during perioperative cerebral hypoperfusion

2020-02-17

Abstract excerpt

<title>Abstract</title> <p>Background: Perioperative cerebral hypoperfusion (CH) is common, although the underlying mechanism of cognitive impairment that results due to perioperative cerebral hypoperfusion remains to be determined. Isoflurane anaesthesia induces neuronal injury via endoplasmic reticulum (ER) stress, whereas a sub-anaesthetic dose of propofol improves postoperative cognitive function. However, th...

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Literature Corpus work
e6cdf908-e1cb-582d-85be-0042dbcba4aa
DOI
10.21203/rs.2.14325/v5
Open publication

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