Article

Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms

2020-07-24

Abstract excerpt

The seven human 14-3-3 isoforms, highly similar yet encoded by distinct genes, are among the top 1% highest-expressed human proteins. 14-3-3 proteins recognize phosphorylated motifs within numerous human or viral proteins. We analyzed by crystallography, fluorescence polarization, mutagenesis and fusicoccin-mediated modulation the structural basis and druggability of 14-3-3 binding to four E6 oncoproteins of tumor...

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Literature Corpus work: 69bfb071-7765-5c54-9cc5-fc683b2c80ab
DOI: 10.1101/2020.07.24.220376

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