Article

p53-dependent polyploidisation after DNA damage in G2 phase

2020-06-10

Abstract excerpt

Cell cycle progression in the presence of damaged DNA can lead to accumulation of mutations and pose a risk for tumour development. In response to DNA damage in G2 phase, human cells can be forced to exit the cell cycle in a p53-p21- and APC/C Cdh1 -dependent manner. Cells that exit the cell cycle in G2 phase become senescent, but it is unclear what determines this commitment and whether other cell fates occur. W...

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Literature Corpus work: d32c0820-0dc1-544c-9bd7-40a71fb5faec
DOI: 10.1101/2020.06.09.141770

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