Article

Multimodal induction of fulminant HLH by IL-18 includes virus-specific NK immunodeficiency

2025-07-08

Abstract excerpt

Macrophage Activation Syndrome (MAS) is a cytokine storm syndrome associated with Still’s Disease, XIAP deficiency, and elevation of both total and free IL-18. Modeling excess IL-18 using Il18tg mice, we found mild NK-cytopenia and cytotoxic T lymphocyte (CTL) activation in resting mice reminiscent of Still’s patients. Infection with Lymphocytic Choriomeningitis Virus (LCMV) triggered MAS via and IFNγ, despite no...

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Literature Corpus work: d306ac70-1516-565a-aec5-1480cc641e8d
DOI: 10.1101/2025.07.04.663237

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