Type I Natural Killer T Cells Suppress Infection-Induced Hypercytokinemia via an IL-22–Dependent Mechanism

Abstract excerpt

Severe infections can trigger systemic inflammatory response syndrome (SIRS), wherein excessive cytokine release generates a “cytokine storm” causing tissue damage, multiorgan failure, and death. Natural killer T (NKT) cells are innate-like lymphocytes that respond rapidly to infection and can either amplify or suppress inflammation. Distinct NKT subsets may have opposing roles in acute infection, but their specif...

Topics

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• Adaptive Immunity
• Cytotoxicity, Immunologic
• Hypersensitivity
• IL-33, ST2, and ILC Pathways
• Infection Control
• Infections
• Th2 Cells
• Toll-Like Receptors

Identifiers and source

Literature Corpus work

37198af1-1d8a-5c89-94a0-fa60ee2bd8a6

DOI

10.64898/2026.06.14.731971