Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inherited IL-18BP deficiency in human fulminant viral hepatitis

18 Jun 2019

Abstract excerpt

Fulminant viral hepatitis (FVH) is a devastating and unexplained condition that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. We report a child who died of FVH upon infection with hepatitis A virus (HAV) at age 11 yr and who was homozygous for a private 40-nucleotide deletion in IL18BP, which encodes the IL-18 binding protein (IL-18BP). This mutation is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis Viruses Studies and Epidemiology
Share to Inflammasome and immune disorders
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31213488
DOI: 10.1084/jem.20190669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inherited IL-18BP deficiency in human fulminant viral hepatitisPMID 31213488Read ↗

Genetic and autoimmune predispositions to fulminant viral hepatitis in children.Semantic proximity Read ↗

IL-18 and IL-18BP: A Unique Dyad in Health and DiseaseSemantic proximity Read ↗

Interleukin-18 Binding Protein in Immune Regulation and Autoimmune DiseasesSemantic proximity Read ↗

Mechanisms of Hepatocellular Injury in Hepatitis ASemantic proximity Read ↗

Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiencySemantic proximity Read ↗

Dominant-negative NFKBIA mutation promotes IL-1β production causing hepatic disease with severe immunodeficiency.Semantic proximity Read ↗

Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive StateSemantic proximity Read ↗

Interleukin‑18 binding protein: Biological properties and roles in human and animal immune regulation (Review)Semantic proximity Read ↗

Multimodal induction of fulminant HLH by IL-18 includes virus-specific NK immunodeficiencySemantic proximity Read ↗

Loss of ADAM17 is associated with severe multiorgan dysfunction.Semantic proximity Read ↗

Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndromeSemantic proximity Read ↗

IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.