Article

Role of<i>DOCK8</i>in Hyper-inflammatory Syndromes

2024-02-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cytokine storm syndromes (CSS), including hemophagocytic lymphohistiocytosis (HLH), are increasingly recognized as hyper-inflammatory states leading to multi-organ failure and death. Familial HLH (FHL) in infancy results from homozygous genetic defects in perforin-mediated cytolysis by CD8 T-lymphocytes and natural killer (NK) cells. Later onset CSS are frequently associated w...

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Literature Corpus work: 1eb18958-1f96-5fdb-a45a-cd6420597d9f
DOI: 10.1101/2024.02.20.24303049

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