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Article

CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2017

Chellappa Stalin, Hugenschmidt Harald, Hagness Morten, Subramani Saranya, Melum Espen, Line Pål Dag, Labori Knut-Jørgen, Wiedswang Gro, Taskén Kjetil, Aandahl Einar Martin

Abstract excerpt

CD8+ T cells that express retinoic acid-related orphan receptor (ROR)γt (TC17 cells) have been shown to promote procarcinogenic inflammation and contribute to a tolerogenic microenvironment in tumors. We investigated their phenotype and functional properties in relationship to the pathogenesis of human distal bile duct cancer (DBDC). DBDC patients had an elevated level of type 17 immune responses and the...

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PMID: 28053236
DOI: 10.4049/jimmunol.1600061

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