Back to search

Article

Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)

2025-04-04

Abstract excerpt

Throughout history, herbal medicines and natural products have played a crucial role as therapeutics for humans, yet their molecular mechanisms of action often remain elusive. Here, we ask whether primulagenin A (PGA) from the traditionally used herbal substance Primula root, acts via the nuclear receptor RORγ, a key regulator of pro-inflammatory Th17 cells, which are linked to autoimmune diseases like psoriasis....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
60ea5bee-ac7b-5bbd-92cc-fa80f3fad8db
DOI
10.1101/2025.04.01.646598
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)DOI 10.1101/2025.04.01.646598
Retinoic acid receptor-related orphan receptor gamma-t (RORγt) inhibitors in clinical development for the treatment of autoimmune diseases: a patent review (2016-present)Semantic proximity
Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivoSemantic proximity
Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivoSemantic proximity
Transcription Factor Retinoid-Related Orphan Receptor γt: A Promising Target for the Treatment of PsoriasisSemantic proximity
Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cellsSemantic proximity
The Therapeutic Potential of Phytochemicals Unlocks New Avenues in the Management of Rheumatoid ArthritisSemantic proximity
RORγt and RORα signature genes in human Th17 cellsSemantic proximity
Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment.Semantic proximity
Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and MetabolismSemantic proximity
Unraveling the Therapeutic Mechanism of Saussurea involucrata against Rheumatoid Arthritis: A Network Pharmacology and Molecular Modeling-Based InvestigationSemantic proximity
Deciphering the pharmacological mechanism of Radix astragali for allergic rhinitis through network pharmacology and experimental validationSemantic proximity
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper CellsSemantic proximity
Select a neighboring publication to make it the new centre.