Article
Impaired capsular polysaccharide is relevant to enhanced biofilm formation and lower virulence in Streptococcus pneumoniae.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Apr 2013
Qin Liang, Kida Yutaka, Imamura Yoshihiro, Kuwano Koichi, Watanabe Hiroshi
Abstract excerpt
Streptococcus pneumoniae has been reported to form biofilms. Many different surface molecules, including capsular polysaccharide (CPS), may play a fundamental role in pneumococcal biofilm development. We designed a CPS mutant, TIGR4cps4D(-), from the TIGR4 strain and detected enhanced biofilm formation. The pathogenic diversities of the mutant were also investigated with the in vitro expression levels of pavA,...
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