Article
Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas.
Clinical & experimental metastasis - 1 Jun 2014
Jones Jacqueline, Wang Honghe, Karanam Balasubramanyam, Theodore Shaniece, Dean-Colomb Windy, Welch Danny R, Grizzle William, Yates Clayton
Abstract excerpt
The expression and biological consequences of Kaiso, a novel bi-modal transcription factor, in infiltrating ductal carcinomas (IDCs) have not been widely investigated. In the present study, we determined Kaiso expression and subcellular localization in 146 normal tissues, 376 IDCs, and 85 lymph node metastases. In IDCs, there was higher Kaiso expression in both the cytoplasmic and nuclear compartments, which...
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