Article
Molecular cloning of two rat GRK6 splice variants.
The American journal of physiology - 1 Sept 1997
Firsov D, Elalouf J M
Abstract excerpt
Desensitization of G protein-coupled receptors is frequently triggered by G protein-coupled receptor kinases (GRKs) that preferentially phosphorylate agonist-occupied receptors. In this study, two GRK6 splice variants were cloned from the rat kidney. One isoform (GRK6a) encodes a 576-amino acid protein that is virtually identical (98% identity) to human GRK6. The second isoform is similar except for a 2-base pair...
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