Article

Exploring Pathogenic Mutation in Allosteric Proteins: the Prediction and Beyond

2024-03-27

Abstract excerpt

Allosteric regulation that triggers the functional activity of a protein through conformational changes is an inherent function of the protein in numerous physiological and pathological scenarios. In the post-genomic era, a central challenge for disease genomes is the identification of the biological effects of specific somatic variants on allosteric proteins and the phenotypes they influence during the initiation...

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Literature Corpus work: 562f0aaa-17c2-5512-b0ac-8a7f96f56757
DOI: 10.1101/2024.03.23.586438

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