Article

Allo-Allo: Data-efficient prediction of allosteric sites

2024-09-30

Abstract excerpt

Allostery, a fundamental structural mechanism where ligand binding at a protein site affects protein function at another site, plays a crucial role in key drug-target proteins like GPCRs. Unfortunately, existing methods for predicting allosteric sites have limited performance– they are particularly constrained by scarce ground-truth experimental data. We introduce Allo-Allo, a data-efficient, sequence-based method...

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Literature Corpus work: 1100bd01-f507-5eec-8a4d-3f8d71241af2
DOI: 10.1101/2024.09.28.615583

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