Article

Defective ribosome assembly impairs leukemia stem cell function in a murine model of acute myeloid leukemia

2023-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Despite the advanced understanding of disease mechanisms, the current therapeutic regimen fails to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of protein synthesis control in AML leukemia stem cell (LSC) function and leukemia propagation. We apply a murine model of mixed-lineage leukemia-rearranged AML to demonstrate that LSCs are characterized...

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Literature Corpus work: d270cd71-1515-5722-ac75-9c272997dace
DOI: 10.1101/2023.01.22.525120

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