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Article

A muscle-specific calpain, CAPN3, forms a homotrimer.

Biochimica et biophysica acta. Proteins and proteomics - 1 Jul 2020

Hata Shoji, Doi Naoko, Shinkai-Ouchi Fumiko, Ono Yasuko

Abstract excerpt

Calpain-3 (CAPN3), a 94-kDa member of the calpain protease family, is abundant in skeletal muscle. Mutations in the CAPN3 gene cause limb girdle muscular dystrophy type 2A, indicating that CAPN3 plays important roles in muscle physiology. CAPN3 has several unique features. A crystallographic study revealed that its C-terminal penta-EF-hand domains form a homodimer, suggesting that CAPN3 functions as a homodimeric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32200007
DOI: 10.1016/j.bbapap.2020.140411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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