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Article

Muscle-specific calpain-3 is phosphorylated in its unique insertion region for enrichment in a myofibril fraction.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Nov 2014

Ojima Koichi, Ono Yasuko, Hata Shoji, Noguchi Satoru, Nishino Ichizo, Sorimachi Hiroyuki

Abstract excerpt

CAPN3 (also called p94/calpain-3) is a skeletal muscle-specific calpain, an intracellular cysteine protease. Loss of CAPN3 protease activity and/or structural functions cause limb-girdle muscular dystrophy type 2A (LGMD2A). However, the precise mechanism of action of CAPN3 in skeletal muscles in vivo remains largely elusive. By studying the protein modifications that regulate CAPN3 activity, we found that CAPN3...

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Share to Calpain
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle Proteins

Share to Muscular Dystrophies, Limb-Girdle

Share to Mutagenesis, Insertional

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Source

Identifiers

PMID: 25252031
DOI: 10.1111/gtc.12181

Genes

CAPN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Muscle-specific calpain-3 is phosphorylated in its unique insertion region for enrichment in a myofibril fraction.PMID 25252031Read ↗

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