Article
Third filament diseases.
Advances in experimental medicine and biology - 1 Jan 2008
Udd Bjarne
Abstract excerpt
The backbone of the third filament system of the sarcomere is the huge titin molecule, spanning from the sarcomeric Z-disc to the M-line. Proteins in direct interaction and functionally integrated with titin, such as calpain 3 and telethonin, are part of the third filament system. The third filament system provides support to the contractile filament systems during development and mature states including...
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