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Article

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

11 May 2004

Abstract excerpt

The giant protein titin serves a primary role as a scaffold for sarcomere assembly; however, proteins that mediate this remodeling have not been identified. One potential mediator of this process is the protease calpain 3 (C3), the protein mutated in limb girdle muscular dystrophy type 2A. To test the hypothesis that C3 mediates remodeling during myofibrillogenesis, C3 knockout (C3KO) mice were generated. The...

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PMID: 15138196
DOI: 10.1093/hmg/ddh153

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Related research

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Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitroPMID 15138196Read ↗

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