Article
Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo.
Atherosclerosis - 1 Nov 2016
Bekkering Siroon, van den Munckhof Inge, Nielen Tim, Lamfers Evert, Dinarello Charles, Rutten Joost, de Graaf Jacqueline, Joosten Leo A B, Netea Mihai G, Gomes Marc E R, Riksen Niels P
Abstract excerpt
BACKGROUND AND AIMS: We have recently reported that monocytes can undergo functional and transcriptional reprogramming towards a long-term pro-inflammatory phenotype after brief in vitro exposure to atherogenic stimuli such as oxidized LDL. This process is termed 'trained immunity', and is mediated by epigenetic remodeling and a metabolic switch towards increased aerobic glycolysis. We hypothesize that trained...
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